Abstract
The novel coronavirus disease is a rapidly spreading infection caused by recently discovered different variants of SARS CoV-2 viruses, causing mild to severe respiratory symptoms in the majority of people. The Coronavirus disease 2019 pandemic has spread almost all the nooks and corners of the world. There are significant possible approaches pharmaceutically to fight against COVID-19. Original full-text research articles were searched online in PubMed, ScienceDirect, ResearchGate, Google Scholar, Core and Wiley Online Library. Scientists throughout the world are working on different platforms and targeting certain proteins moieties against SARS CoV-2 for the development of methods of safety, efficacy and potential vaccine candidates. Many candidates showed efficacy in In-vitro studies but relatively few clinical studies proceeded through different vaccine development platforms, such as entire virus vaccines, plant-based and nucleic acid vaccines, recombinant protein subunit vaccines. This review study provides a short description of SARS-CoV-2 characteristics and deals with recent developments in the design of attempts to produce vaccines to combat COVID-19.
Highlights
The SARS-CoV is a single-strand protected virus lipid membrane (M, E, & S glycoproteins) which may be enabled by ACE2 as a functional receptor that mediates viral entrance into host target cells [1,2]
SARS-CoV-2 binds to the ACE2 receptor, the DPP4 cellular receptor is the target of MERS-S in the N-terminal surface subunit via RBDMERS-molecular CoV's interaction with hCD26 was delineated
Prevailing data indicate that S protein and ACE2 receptor proteolytic cleavage is a necessary step to block the entrance of SARS-CoV-2 into the host cells [19]
Summary
Cite This Paper in the following Citation Styles (a): [1] Sonam Bhutia, Bibhuti Bhusan Kakoti, Prosanta Pal , "The Recent Developmental Platforms and Potential Targets of SARS CoV-2 Vaccines: A Comprehensive Review," Advances in Pharmacology and Pharmacy, Vol 9, No 4, pp. 127 - 138, 2021. Cite This Paper in the following Citation Styles (a): [1] Sonam Bhutia, Bibhuti Bhusan Kakoti, Prosanta Pal , "The Recent Developmental Platforms and Potential Targets of SARS CoV-2 Vaccines: A Comprehensive Review," Advances in Pharmacology and Pharmacy, Vol 9, No 4, pp. (b): Sonam Bhutia, Bibhuti Bhusan Kakoti, Prosanta Pal (2021). The Recent Developmental Platforms and Potential Targets of SARS CoV-2 Vaccines: A Comprehensive Review. Advances in Pharmacology and Pharmacy, 9(4), 127 - 138.
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