7-days of FREE Audio papers, translation & more with Prime
7-days of FREE Prime access
7-days of FREE Audio papers, translation & more with Prime
7-days of FREE Prime access
https://doi.org/10.1016/s0040-4039(00)72648-7
Copy DOIJournal: Tetrahedron Letters | Publication Date: Jan 1, 1975 |
Citations: 11 |
The imidazole group, which is a part of the active centre of many enzymes, often dieplays an unusual reactivity '. It is intereeting to find out which role in this phenomenon is played by the effects of the microenvironment. It is known that there are certain analogiee between the structure of protein globules and aurfactant micellee 2-4 . Hence we believed it feasible to elucidate how the reactivity of imidazole derivative6 ie affected by the environment of the surface layer of cetyltrimethylammonium bromide (CTAB) micelles. We have meaeured the liberation of p-nitrophenate ion on acylation of a series of imidazole derivatives (see legend to the figure) by p-nitrophenylheptanoate, under conditions when the concentration of the nucleophile greatly exceeds that of the ester. The true rate constanta for this reaction in micellee were calculated from the observed reaction rate va. CTAB concentration profilee. To this end we used the kinetic method 5-7 developed previouely for other reactions. It should be emphasized that thie approach to the analyaie of the overall kinetic data makes it possible to estimate the contribution to the micellar effect of the partition of the reagents between the bulk end micellar phaeee. The second order rate constant8 found reflect the true reactivity of the reagente in the micellar environment. Study of the pH dependence allowed
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.