The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency

Abstract

The paper presents a comparative analysis of data on the effect of moderate and acute hypoxia on the functional state of systems at various levels of organization - molecular (amide groups of brain proteins), cellular (background electrical activity of neurons), systemic (electroencephalogram - EEG, electrocardiogram (ECG) and organismic (integrative signal of the body). Changes in electrographic parameters have an adaptive meaning for the body and are of a phase nature: in moderate hypoxia (4500-5000 m) the indicators are activated, and at acute hypoxia (7500 - 8000 m) - are depressed. 15-30 minutes after exposure to hypoxia at normal atmospheric pressure, the values of almost all indicators are back to normal. It is shown, that a prolonged aftereffect of acute hypoxia is observed at the organism molecular level. Under oxygen deficiency, the number of amide groups of brain proteins increases. After the hypoxic factor, this violation persists for a day. The data of the influence of hypoxia on animals, lead to the conclusion, that the functional systems of different levels of organization react ambiguously to the impact of increasing oxygen deficiency. However, in the dynamics of hypoxia in the values of the integrative signal recorded by a non-invasive method from the body surface, phase changes are not observed, on the contrary, the shifts are unidirectional. Certain deviations of the indicators of the integrative signal in the phase of moderate hypoxia increase during acute hypoxia and continue for several hours. We conclude that the remote "Bioscope" signal being integral in nature, is not the sum of individual electrographic indicators of various functional systems and has a high sensitivity and specificity to the change of physiological state of animal.