Abstract
THE REACTION OF PYRIDINE NUCLEOTIDES WITH TRIFLUOROACETIC ACID ANHYDRIDE
Highlights
Further investigation and similar experiments with diphosphopyridine nucleotide (DPN) showed that what apparently did take place was a selective cleavage of the pyrophosphate linkage, followed by a recombination of part of the resulting fragments to yield several new compounds
1.3 1.4 6.2 0 the value nosine could be releasedfrom the Trifluoroacetic acid anhydride (TFAA) products by the action of diesterase and monoesterase,which are present, in the same manner that it is releasedfrom triphosphopyridine nucleotide (TPN)
These results indicate that there is a greater tendency for the formation of (NR)zPOP than for the synthesis of DPN
Summary
The initial reaction in this case is believed to involve the formation of a mixed anhydride of trifluoroacetic acid and nucleoside phosphoric acid This mixed anhydride forms the cyclic phosphate ester with the adjacent free hydroxyl of the ribose moiety. Further investigation and similar experiments with diphosphopyridine nucleotide (DPN) showed that what apparently did take place was a selective cleavage of the pyrophosphate linkage, followed by a recombination of part of the resulting fragments to yield several new compounds. One of these compounds obtained by treating DPN with TFAA has been identified as diadenosine-5’-pyrophosphate ((AR) ZPOP).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
