The reaction of carbon disulphide with α-haloketones and primary amines in the presence of potassium iodide as catalyst

Abstract

A simple, mild and convenient method has been developed for the synthesis of 3,4,5-trialkyl-1,3-thiazole-2(3H)-thione derivatives through one pot three-component reaction between a primary amine, carbon disulphide, and α-haloketone in the presence of potassium iodide at room temperature conditions. The products were obtained with excellent yield and appropriate reaction times. This reaction represents a rapid and unprecedented route to the described molecules that have biological specifications. One-pot three-component reaction of primary amines, carbon disulphide and α-haloketone catalysed by potassium iodide (KI) via a simple, fast, mild and efficient method is reported.