Abstract
Methods: 20 CAPD anuria patients without peritonitis in our peritoneal dialysis center were recruited from July 2016 to July 2018. These patients were divided into high-transport peritoneum group and non-high transport peritoneum group according to peritoneal transport type. Patients from both groups received the same dialysis solutions and dialysis modality. Peritoneal transport type, serum C-reactive protein, peritoneal equilibrium test results, dialysate NGAL, plasm NGAL, the ratio of dialysate NGAL to plasm NGAL (D/P NGAL) from both groups were recorded. Spearman’s correlation coefficient was employed to examine the relations between variables. Receiver operating characteristic (ROC) curve analysis was used to calculate the area under the curve (AUC) for ratio of dialysate NGAL to plasm NGAL (D/P NGAL) and peritoneal creatinine to serum creatinine (D/P creatinine).
Highlights
Peritoneal dialysis (PD) is a renal replacement therapy which is used by approximately 11% of the total global dialysis population [1]
Plasm Neutrophil gelatinase-associated lipocalin (NGAL) is known to be high in patients with CKD [3], and high plasm NGAL is positively correlated with peritoneal NGAL in PD patients
No relationship existed between plasm NGAL and D/P creatinine, plasm NGAL and D/D0 glucose (p=0.41, p=0.08 respectively shown in Figure 1a & 2a)
Summary
Peritoneal dialysis (PD) is a renal replacement therapy which is used by approximately 11% of the total global dialysis population [1]. Neutrophil gelatinase-associated lipocalin (NGAL) is a secretive glycoprotein which belongs to lipoprotein superfamily. It consists of 178 amino acids with a relative molecular weight of 25 KDa. The human NGAL gene is located in the long arm of the No 9 chromosome (9q34) and contains 5’ non-transcription regions, 3’ non-transcription regions, seven exons and six introns. It is reported that neutrophil gelatinase-associated lipocalin in peritoneal dialysis could reflects status of peritoneum [5], as evidenced by an inverse correlation between dialysate NGAL and peritoneal ultrafiltration volume [3]. To rule out the impact of inflammation and residual renal function on dialysate NGAL, we recruited continuous ambulatory peritoneal
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