2082081 Evaluation of Virtual Touch IQ Shear Wave Velocity for Solid Breast Masses

Abstract

ObjectivesVirtual Touch IQ is a relatively new method of shear wave (SW) elastography, and it has not yet been subjected to adequate studies. In this study, we evaluated the SW velocities characteristic of benign and malignant breast masses using Virtual Touch IQ, and compared with fat lesion ratio (FLR) of strain elastography.MethodsBetween January and August of 2014, B-mode ultrasound, SW elastography were performed on 114 solid breast masses (malignant 73, benign 41) using the ACUSON S3000 (Siemens Medical Solutions). On 101 of the 114 masses, strain elastography was also performed using the HI VISION Preirus (Hitachi Aloka Medical). The SW velocity was evaluated at the highest SW velocity point (2 mm square) on the Virtual Touch IQ display. For each mass, the SW velocity and FLR were measured three times, and the median value of these measurements was used in this study. Regarding the Virtual Touch IQ, the area under the curve (AUC) and optimal cutoff values were assessed using a receiver operating characteristic (ROC) curve analysis. Regarding the FLR, we used a cutoff value of 5.0.ResultsThe mean patient age was 51.0+-14.2 years (range: 22-85 yrs). The median tumor size was 2.1+-1.5 cm (range: 0.6-11.8 cm) in malignant masses and 2.0+-1.8 cm (range: 0.5-10.7 cm) in benign masses. The mean velocity was 7.5 +-1.5 m/s (range: 3.1-10.0 m/s) in malignant masses and 4.4+-1.4 m/s (range: 2.2-7.4 m/s) in benign masses. The SW velocity was significantly higher in the malignant masses than in benign masses (p = 0.0001). An ROC curve analysis yielded an AUC of 0.93. Based on the Youden index, the optimal cutoff value was 6.5 m/s (sensitivity, 0.81; specificity, 0.93; PPV, 0.95; NPV, 0.73). The FLR was significantly higher (P=0.001) in malignant masses (17.0+-21.2, range: 1.4-114.1) than benign masses (4.2+-5.5, range: 0.3-30.0). Sensitivity, specificity, PPV and NPV of FLR were 0.85, 0.87, 0.93, 0.67, respectively. Pearson’s correlation coefficient of SW velocity and FLR was 0.33 (p=0.001).ConclusionsThis study suggested that the Virtual Touch IQ SW velocity was useful for the differential diagnosis of solid breast masses. Weak significant correlation was observed between SW velocity and FLR. ObjectivesVirtual Touch IQ is a relatively new method of shear wave (SW) elastography, and it has not yet been subjected to adequate studies. In this study, we evaluated the SW velocities characteristic of benign and malignant breast masses using Virtual Touch IQ, and compared with fat lesion ratio (FLR) of strain elastography. Virtual Touch IQ is a relatively new method of shear wave (SW) elastography, and it has not yet been subjected to adequate studies. In this study, we evaluated the SW velocities characteristic of benign and malignant breast masses using Virtual Touch IQ, and compared with fat lesion ratio (FLR) of strain elastography. MethodsBetween January and August of 2014, B-mode ultrasound, SW elastography were performed on 114 solid breast masses (malignant 73, benign 41) using the ACUSON S3000 (Siemens Medical Solutions). On 101 of the 114 masses, strain elastography was also performed using the HI VISION Preirus (Hitachi Aloka Medical). The SW velocity was evaluated at the highest SW velocity point (2 mm square) on the Virtual Touch IQ display. For each mass, the SW velocity and FLR were measured three times, and the median value of these measurements was used in this study. Regarding the Virtual Touch IQ, the area under the curve (AUC) and optimal cutoff values were assessed using a receiver operating characteristic (ROC) curve analysis. Regarding the FLR, we used a cutoff value of 5.0. Between January and August of 2014, B-mode ultrasound, SW elastography were performed on 114 solid breast masses (malignant 73, benign 41) using the ACUSON S3000 (Siemens Medical Solutions). On 101 of the 114 masses, strain elastography was also performed using the HI VISION Preirus (Hitachi Aloka Medical). The SW velocity was evaluated at the highest SW velocity point (2 mm square) on the Virtual Touch IQ display. For each mass, the SW velocity and FLR were measured three times, and the median value of these measurements was used in this study. Regarding the Virtual Touch IQ, the area under the curve (AUC) and optimal cutoff values were assessed using a receiver operating characteristic (ROC) curve analysis. Regarding the FLR, we used a cutoff value of 5.0. ResultsThe mean patient age was 51.0+-14.2 years (range: 22-85 yrs). The median tumor size was 2.1+-1.5 cm (range: 0.6-11.8 cm) in malignant masses and 2.0+-1.8 cm (range: 0.5-10.7 cm) in benign masses. The mean velocity was 7.5 +-1.5 m/s (range: 3.1-10.0 m/s) in malignant masses and 4.4+-1.4 m/s (range: 2.2-7.4 m/s) in benign masses. The SW velocity was significantly higher in the malignant masses than in benign masses (p = 0.0001). An ROC curve analysis yielded an AUC of 0.93. Based on the Youden index, the optimal cutoff value was 6.5 m/s (sensitivity, 0.81; specificity, 0.93; PPV, 0.95; NPV, 0.73). The FLR was significantly higher (P=0.001) in malignant masses (17.0+-21.2, range: 1.4-114.1) than benign masses (4.2+-5.5, range: 0.3-30.0). Sensitivity, specificity, PPV and NPV of FLR were 0.85, 0.87, 0.93, 0.67, respectively. Pearson’s correlation coefficient of SW velocity and FLR was 0.33 (p=0.001). The mean patient age was 51.0+-14.2 years (range: 22-85 yrs). The median tumor size was 2.1+-1.5 cm (range: 0.6-11.8 cm) in malignant masses and 2.0+-1.8 cm (range: 0.5-10.7 cm) in benign masses. The mean velocity was 7.5 +-1.5 m/s (range: 3.1-10.0 m/s) in malignant masses and 4.4+-1.4 m/s (range: 2.2-7.4 m/s) in benign masses. The SW velocity was significantly higher in the malignant masses than in benign masses (p = 0.0001). An ROC curve analysis yielded an AUC of 0.93. Based on the Youden index, the optimal cutoff value was 6.5 m/s (sensitivity, 0.81; specificity, 0.93; PPV, 0.95; NPV, 0.73). The FLR was significantly higher (P=0.001) in malignant masses (17.0+-21.2, range: 1.4-114.1) than benign masses (4.2+-5.5, range: 0.3-30.0). Sensitivity, specificity, PPV and NPV of FLR were 0.85, 0.87, 0.93, 0.67, respectively. Pearson’s correlation coefficient of SW velocity and FLR was 0.33 (p=0.001). ConclusionsThis study suggested that the Virtual Touch IQ SW velocity was useful for the differential diagnosis of solid breast masses. Weak significant correlation was observed between SW velocity and FLR. This study suggested that the Virtual Touch IQ SW velocity was useful for the differential diagnosis of solid breast masses. Weak significant correlation was observed between SW velocity and FLR.