The Radioprotective Effect of Polyphenols From Pinecones of Pinus koraiensis and Their Synergistic Effect With Auricularia auricula‐judae (Bull.) J. Schröt Polysaccharides

Abstract

The objectives of this work are to investigate the protective effect of Polyphenols from pinecones of Pinus koraiensis (PPPK) on damage caused by radiation in mice, and to test for its potential synergism with Auricularia auricula‐judae (Bull.) J. Schröt Polysaccharides (AAP). Male mice are administered for 30 days prior to radiation, and the combination index (CI) is used for the synergistic effect analysis. The results show that PPPK exhibited significant radioprotective effects compared with radiation group (P < 0.01); PPPK in combination with AAP had higher anti‐radiation effects, as evident by improved white blood cells (P < 0.01), organ indexes (P < 0.05 or 0.01), splenic lymphocytes proliferation activity (P < 0.01), bone marrow DNA content (P < 0.01), and monocyte phagocytic activity (P < 0.05), relative to other groups; the combination also reduced bone marrow micronucleus rate (P < 0.01) and chromosome distortion rate (P < 0.01). These data for the first time demonstrated the radioprotective effect of PPPK and its synergistic effect with AAP.