Abstract
The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated limb. The remarkable advances in the scientific understanding of regeneration, stem cell science, material science and engineering, physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound healing. Here we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.
Highlights
Regeneration of complex tissues and organ systems such as a knee or whole limb has remained a clinical fascination in the 20th century
Even though the key signaling pathways involved in blastema formation and subsequent regenerative processes are not well understood, studies have shown that some of the pathways that control embryonic limb formation such as fibroblast growth factor (FGF) and wnt-b catenin signaling are essential [16, 17]
The limitations of the current biological and engineering approaches towards limb regeneration show that a paradigm shift is required to successfully address this Grand Challenge
Summary
Regeneration of complex tissues and organ systems such as a knee or whole limb has remained a clinical fascination in the 20th century. Even though the key signaling pathways involved in blastema formation and subsequent regenerative processes are not well understood, studies have shown that some of the pathways that control embryonic limb formation such as fibroblast growth factor (FGF) and wnt-b catenin signaling are essential [16, 17].
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