The Protective Effects of a Combination of an Arginine Silicate Complex and Magnesium Biotinate Against UV-Induced Skin Damage in Rats (P06-028-19)

Abstract

ObjectivesSkin appearance and function begin to decline as humans age due to physiological changes as well as external factors such as prolonged sun exposure and inadequate nutrient intake. Replenishing the body with nutrients such as silicon and biotin has been shown to improve skin appearance. JDS-ASB is a novel combination of inositol-stabilized arginine silicate complex (ASI), a highly bioavailable form of arginine and silicon, and magnesium biotinate (MgB), a novel, well-absorbed biotin salt. This study was conducted to observe the effects of JDS-ASB on skin appearance and health in rats chronically exposed to ultraviolet (UV) radiation. MethodsThirty-five female Sprague-Dawley rats (8-weeks old) were randomized into one of the following groups; 1: Control (no treatment), 2: UV (exposed to UV radiation with no other treatment), 3: UV + ASI + Low Dose MgB (140 mg human equivalent dose (HED) of ASI and 1.5 mg HED of MgB), 4: UV + ASI + High Dose MgB (140 mg HED of ASI and 10 mg HED of MgB), 5: UV + ASI + High Dose MgB (140 mg HED of ASI and 10 mg HED of MgB) + MgB cream (10 mg HED). Rat diets included egg whites to standardize absorbable biotin levels. Rats had a dorsal area of hair shaved throughout the study and were exposed to UV lamps five times per week. Each day rats were dosed with study product by oral gavage and/or cream two hours before UV exposure for ten weeks. ResultsRats exposed to UV radiation with no other treatment showed significant signs of skin damage. Skin appearance score improved with all treatments compared to UV exposure alone (p < 0.05). This parameter improved the most in group 5 compared to all treatment groups (p < 0.05), with scores similar to control, while scores did not differ between groups 3 and 4 (Figure 1). Skin elasticity evaluation showed similar results. Inflammatory cell levels in the skin were lower and collagen content was higher in all treatment groups compared to UV exposure alone (p < 0.05). In group 5, inflammatory cells were no different than control levels, and collagen content was the highest compared to all treatment groups (p < 0.05). ConclusionsTreatment with ASI and MgB strongly protects against the skin damage that results from chronic UV exposure. The addition of a 10 mg MgB cream further increases the ability of JDS-ASB to improve skin appearance, elasticity, inflammation, and overall health. Funding SourcesThis study was funded by JDS Therapeutics, LLC. Supporting Tables, Images and/or Graphs▪