Abstract
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property.
Highlights
G astric and duodenal ulcers are commonly known as peptic ulcers, which are defined as mucosal erosions with at least half a centimeter intrusive diameter in the human mucosa [1]
After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples
The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes
Summary
G astric and duodenal ulcers are commonly known as peptic ulcers, which are defined as mucosal erosions with at least half a centimeter intrusive diameter in the human mucosa [1]. The most common complications of this disease include bleeding, perforation, and obstruction [2]. One of the main etiologic factors in the development of chronic gastric ulcers is the consumption of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including indomethacin, naproxen and ibuprofen [6, 7]. Factors such as increased gastric acid, alcohol consumption, smoking, severe stress, and other chronic conditions can increase the risk of gastric mucosal ulcers [8]. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats
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