Effects of Tannic Acid and Daily Intraperitoneal Beryllium Injections on Adult Male Albino Rats: Distribution and Physiological Hazards in Body Organs

Abstract

Background: Beryllium (Be) is an element used in various industries, such as nuclear and microelectronic industries. Be release into the environment raises its toxic effects and increases the likelihood of exposure to humans, which causes many hazardous side effects, such as cancer and skin allergic conditions. Methods: This study investigated the role of tannic acid (TA) in counteracting the hazardous effects and the accumulation of Be. We made daily injections intraperitoneally into 72 adult male albino rats for 14 days. Animals were divided into four groups: control, Be, TA, and Be+TA. The animals were sacrificed at 1, 7, or 14 days into the study. Results: The data provided evidence that Be accumulations were found in different body organs, which were ranked as follows: lung>liver>kidneys>brain>testes. Be accumulations lowered the rats’ blood glucose levels significantly. In addition, the liver function tests showed significant increases in bilirubin and transaminase enzymes in the animals. We also found significant declines in alkaline phosphatase, albumin, and proteins in these animals. Further, significant rises occurred in the kidneys’ secretions of creatinine, urea, uric acid, lipids, cholesterol, and triglycerides. The TA administration ameliorated the toxic effects of Be on all of the tested variables. The rise in malondialdehyde and the decline in glutathione levels in the kidneys and liver improved after the TA treatment. Conclusion: The findings of this study provided evidence that TA administration effectively counteracted the toxic effects of Be administration in rats.