Abstract
Abstract A new, easily accessible and achiral 2′-ketal protective group has been designed for the use in the chemical synthesis of oligoribonucleotides; the proposed 2′-ketal group(1) has the additional advantage that it could be easily functionalized to the diamide (6) with aq. ammonia at the penultimate step of deblocking of oligoribonucleotides which makes it more acid-labile than the parent 2′-ketal group during the final acid-promoted deprotection step.
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