Abstract

BackgroundShort-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore the alteration of SCFAs in patients with diarrhea-predominant IBS (IBS-D) and their potential role in the occurrence and development of IBS.MethodsWe recruited patients with IBS-D defined by Rome IV criteria and age-and-gender matched healthy controls (HCs). A headspace solid-phase microextraction gas chromatography–mass spectrometric (HS-SPME-GC-MS) method was developed for the analysis of acetic, propionic and butyric acid in feces and serum.ResultsCompared with HCs, the levels of the serum propionate (2.957 ± 0.157 vs 2.843 ± 0.098 mmol/L, P = 0.012) and butyrate (2.798 ± 0.126 vs 2.697 ± 0.077 mmol/L, P = 0.012) were significantly higher in IBS-D group. No significant differences were found among two groups with regard to the concentration of fecal acetate (4.953 ± 1.065 vs 4.774 ± 1.465 mg/g, P = 0.679), propionate (6.342 ± 1.005 vs 6.282 ± 1.077 mg/g, P = 0.868) and butyrate (2.984 ± 0.512 vs 3.071 ± 0.447 mg/g, P = 0.607).ConclusionsMetabolites of gut microbiota, the propionic and butyric acid, are increased in patients with IBS-D in serum but not in feces. It suggests that propionic and butyric acid might be associated with the occurrence and development of IBS.

Highlights

  • Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting

  • There were no significant differences in gender, BMI or age between IBS-D patients and healthy controls

  • All patients and healthy controls (HCs) completed the detection of SCFAs in feces and serum

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Summary

Introduction

Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Irritable Bowel Syndrome (IBS) is one of the most common functional bowel disorders characterised by recurrent or chronic abdominal pain accompanied by changes in bowel habits or associated with bowel movements [1]. It affects 7 to 21% of the population worldwide and 1 to 16% in China [2]. It is classified into Diarrhea-predominant IBS, Constipation- predominant IBS (IBS-C), Mixed type. Gut microbiota might be involved in the pathogenesis of IBS by affecting brain-gut axis, activating immune reaction, disturbing gastrointestinal motility, altering mucosal permeability and inducing visceral hypersensitivity [4]

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