Abstract
Primary open angle glaucoma (POAG) is a synthetically genetic heterogeneity in neurodegenerative disease, characterized by a gradual loss of vision. The optineurin (OPTN) gene has already been identified as one of the genes that cause POAG. OPTN mutation may result in structural and functional changes of its protein, optineurin. Optineurin has been shown to bind with a number of specific ligands. Optineurin mutation may break the interactions with proteins or make the function of binding complexes abnormal. The location, the structure of the OPTN gene, binding partners and molecular biology functions of optineurin, and the relationship between the mutation of the OPTN gene and POAG are introduced one by one in this review. Key words: Genes, OPTN; Glaucoma, open-angle; Molecular biology
Published Version
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