Abstract
Objective – to estimate the role of leptin gene polymorphism (Arg223Gln) in progression of chronic heart failure in patients with coronary heart disease and obesity. Matherials and methods. For the purpose of the study, a complex examination of 222 patients with ischemic heart disease (IHD) and obesity was conducted in the cardiology department of the Kharkov City Clinical Hospital № 27, which is the basic medical institution of the Internal Medicine Department № 2 and clinical immunology and allergology of the Kharkov National Medical University of the Ministry of Health of Ukraine. Results. Comparing the frequency of detection of alleles and genotypes of leptin gene (Arg223Gln) depending on the functional class of chronic heart failure (CHF) in patients with coronary heart disease and obesity did not show any possible differences between the subgroups. Differences in the distribution of alleles and genotypes of leptin gene polymorphism (Arg223Gln) based on left ventricular ejection fraction in patients with coronary heart disease and obesity were not established. Conclusion. Thus, the results of our study, show that progression of heart failure in patients with coronary heart disease and obesity do not depend on leptin gene polymorphism (Arg223Gln).
Highlights
The results of our study, show that progression of heart failure in patients with coronary heart disease and obesity do not depend on leptin gene polymorphism (Arg223Gln)
obesity was conducted in the cardiology department of the Kharkov City Clinical Hospital
in patients with coronary heart disease and obesity did not show any possible differences between the subgroups
Summary
ПРОГРЕСУВАННЯ ХРОНІЧНОЇ СЕРЦЕВОЇ НЕДОСТАТНОСТІ ЗАЛЕЖНО ВІД ГЕНОТИПІВ ПОЛІМОРФІЗМУ ГЕНА ЛЕПТИНУ (ARG223GLN) У ХВОРИХ НА ІШЕМІЧНУ ХВОРОБУ СЕРЦЯ Й ОЖИРІННЯ
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