Abstract
Tumor necrosis factor-like attenuated apoptosis inducer (TWEAK) is a new member of the tumor necrosis factor super family. TWEAK regulates cellular proliferation, differentiation, migration, apoptosis and inflammation by binding its receptor, fibroblast growth factor-inducible 14 (Fn14), through the interaction between cells or in a paracrine fashion. The role of TWEAK / Fn14 signaling pathway in the development of lung diseases such as lung injury, asthma and lung cancer has drawn increasing attention. Key words: TNF-related apoptosis-inducing ligand; Receptors, TNF-related apoptosis-inducing ligand; Review
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