Abstract
Background: G Protein Subunit Gamma 7 (GNG7) is an important gene that regulates cell proliferation and induces apoptosis. However, the correlation between GNG7 expression and immune infiltration as well as patient prognosis of colorectal cancer (CRC) remains unclear. Methods: The GNG7 expression differences between tumor tissues and normal tissues were explored via the Oncomine database, Tumor Immune Estimation Resource (TIMER) site and UALCAN database. Then, the influence of GNG7 on clinical prognosis were evaluated, using the PrognoScan database. In addition, the relationship between GNG7 and tumor-related immune infiltration as well as gene marker sets of immune infiltration was investigated via TIMER, TISIDB and GEPIA. Results: We found that GNG7 expression was down-regulated in multiple malignant tumors including colorectal cancer (CRC) and the GNG7 expression was associated with tumor stage, histology subtype, lymph node metastasis and poor prognosis in colorectal cancer (CRC). In addition, the expression of GNG7 was significantly associated with infiltration level of multiple immune cells, immunomodulatory factors as well as part of the immune cell markers. Conclusion: GNG7 displays validated prognostic value in CRC and was associated with its immune cell infiltration and immunoregulation. These results suggest that GNG7 is a potential prognostic marker and is associated with tumor immune infiltration, thus providing a new perspective for the immunotherapy of CRC.
Highlights
In 2020, there were approximately more than 1.9 million new cases of colorectal cancer (CRC) and 935,000 deaths from colorectal cancer globally
It was observed that the G Protein Subunit Gamma 7 (GNG7) expression was up-regulated in kidney cancer, leukemia and lung cancer compared with the normal tissues, while it was down-regulated significantly in some datasets of bladder cancer, brain and CNS cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, leukemia, lymphoma, ovarian cancer and pancreatic cancer (Figure 3A, Supplementary Table S1)
We found that GNG7 expression was down-regulated in COAD and READ, but it was associated with tumor histology, stage, lymph node metastasis according to the result in UALCAN (Figure 4)
Summary
In 2020, there were approximately more than 1.9 million new cases of colorectal cancer (CRC) and 935,000 deaths from colorectal cancer globally. Colorectal cancer accounting for the third most common cancer in the world, but ranks second in terms of mortality (Sung et al, 2021). Surgery is still the cornerstone of the treatment of CRC, but its shortcomings are obvious. Significant progress has been made in the screening, diagnosis, surgery and chemotherapy for patients with colorectal cancer in recent decades, the patients’ clinical benefits acquired from traditional treatment approaches are limited and the patients’ prognosis still needs to be improved. The correlation between GNG7 expression and immune infiltration as well as patient prognosis of colorectal cancer (CRC) remains unclear
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