Abstract
BackgroundlncRNA may be involved in the occurrence, metastasis, and chemical reaction of hepatocellular carcinoma (HCC) through various pathways associated with autophagy. Therefore, it is urgent to reveal more autophagy-related lncRNAs, explore these lncRNAs’ clinical significance, and find new targeted treatment strategies.MethodsThe corresponding data of HCC patients and autophagy genes were obtained from the TCGA database, and the human autophagy database respectively. Based on the co-expression and Cox regression analysis to construct prognostic prediction signature.ResultsFinally, a signature containing seven autophagy-related lncRNAs (PRRT3-AS1, RP11-479G22.8, RP11-73M18.8, LINC01138, CTD-2510F5.4, CTC-297N7.9, RP11-324I22.4) was constructed. Based on the risk score of signature, Overall survival (OS) curves show that the OS of high-risk patients is significantly lower than that of low-risk patients (P = 2.292e−10), and the prognostic prediction accuracy of risk score (AUC = 0.786) is significantly higher than that of ALBI (0.532), child_pugh (0.573), AFP (0.5751), and AJCC_stage (0.631). Moreover, multivariate Cox analysis and Nomogram of risk score are indicated that the 1-year and 3-year survival rates of patients are obviously accuracy by the combined analysis of the risk score, child_pugh, age, M_stage, and Grade (The AUC of 1- and 3-years are 0.87, and 0.855). Remarkably, the 7 autophagy-related lncRNAs may participate in Spliceosome, Cell cycle, RNA transport, DNA replication, and mRNA surveillance pathway and be related to the biological process of RNA splicing and mRNA splicing.ConclusionIn conclusion, the 7 autophagy-related lncRNAs might be promising prognostic and therapeutic targets for HCC.
Highlights
Hepatocellular carcinoma (HCC), as the most common type of liver cancer [1], with high cancer-related mortality and poor prognosis worldwide [2], makes a threat to public health
ALBI score (As) is calculated as = + (− 0.085 * albumin), where bilirubin is in umol/L and albumin in g/L, ALBI grade 1 ≤ − 2.6, ALBI grade 2: − 2.6 < As ≤ − 1.39, and ALBI grade 3: As > − 1.39
Univariate Cox regression indicated thatT (P = 0.005, 95% CI 1.167–2.372), M (P = 0.001, 95% CI 2.222–24.721), Stage (P = 0.002, 95% CI 1.227–2.490), Grade (P = 0.01, 95% CI 1.173–3.249), prothrombin time (PT) (P = 0.024, 95% CI 1.010–1.157), Tbil (P = 0.016, 95% CI 0.683–0.961), risk score (P < 0.001, 95% CI 1.224–1.528) were related to the prognosis (Fig. 4a and Table 2)
Summary
Hepatocellular carcinoma (HCC), as the most common type of liver cancer [1], with high cancer-related mortality and poor prognosis worldwide [2], makes a threat to public health. Molecular alterations of HCC have been reported in some studies [7], and those molecular mechanisms can be explored further in the diagnosis and treatment of HCC [8,9,10]. These efforts have not made a significant improvement in patient survival. LncRNA may be involved in the occurrence, metastasis, and chemical reaction of hepatocellular carcinoma (HCC) through various pathways associated with autophagy. It is urgent to reveal more autophagy-related lncRNAs, explore these lncRNAs’ clinical significance, and find new targeted treatment strategies
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