Abstract
Background Hsp70 (heat shock protein 70) plays a key role in carcinogenesis and cancer progression. However, the relationship between the Hsp70 expression level and the colorectal cancer patient survival is unknown. This study is aimed at investigating the relationship between Hsp70 and the prognosis of colorectal carcinoma patients. Methods PubMed, Web of Science, and Embase were used for systematic computer literature retrieval. Stata SE14.0 software was used for quantitative meta-analysis. Besides, data was extracted from selected articles. Relationships between Hsp70 expression level and prognosis were further studied. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were also computed. Results A total of 11 potentially eligible studies with 2269 patients were identified in 10 tumors from PubMed, Web of Science, and Embase. Hsp70 overexpression was associated with poor overall survival (OS) and disease-free survival (DFS) in colorectal carcinoma patients (HRs, 0.65 (95% CI: 0.52-0.78) and 0.77 (95% CI: 0.23-1.32), respectively). Conclusions Hsp70 overexpression can predict poor survival in colorectal cancer patients.
Highlights
Colorectal cancer (CRC) is a serious health problem worldwide
The prognostic value of the Heat shock protein 70 (Hsp70) expression level in colorectal cancer patients was determined by estimating the hazard ratios between the upregulated and downregulated Hsp70 tissue groups for overall survival or disease-free survival
Meta-analysis of nine articles with 1917 colorectal cancer patients showed that Hsp70 expression was significantly associated with overall survival (OS) (HR 0.65; 95% confidence intervals (95% CIs): 0.520.78; Figure 2), indicating that Hsp70 overexpression is associated with poor survival
Summary
Colorectal cancer (CRC) is a serious health problem worldwide. The response and overall survival of advanced colorectal cancer patients are very poor compared with the early stage. Surgical tumor resection is the major treatment method for local advanced colorectal cancer. Hsps are essential in cellular defense against carcinogenesis [4] Their tumorigenesis role includes oncogenic protein stabilization, programmed cell death, replicative senescence inhibition, tumor angiogenesis induction, invasion, and metastasis activation [5]. The relationship between the Hsp expression level and the colorectal cancer patient survival is unknown. A total of 11 potentially eligible studies with 2269 patients were identified in 10 tumors from PubMed, Web of Science, and Embase. Hsp overexpression was associated with poor overall survival (OS) and disease-free survival (DFS) in colorectal carcinoma patients (HRs, 0.65 (95% CI: 0.52-0.78) and 0.77 (95% CI: 0.23-1.32), respectively). Hsp overexpression can predict poor survival in colorectal cancer patients
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