Abstract
Aim: To evaluate the predictive value of fluorescence level in fundus fluorescein angiography (FFA) images for the prognosis of diabetic macular edema (DME). Material and Methods: In this retrospective study, 21 eyes of 21 patients who have been treated with intravitreal injection (ranibizumab, aflibercept) for DME were evaluated. In addition to demographic features, pre/post-treatment best-corrected visual acuity (BCVA) and central retinal thickness (CRT), early-stage reflectance of fluorescence in FFA were also quantified. The prognostic role of early angiographic reflectance in response to treatment were evaluated. Groups were defined as high or low early fluorescence according to the reflectance level in early angiographic phase. Results: After treatment, mean BCVA was increased and mean CRT was decreased significantly (p<0.05). There was no significant difference between groups regarding BCVA and CRT change (p=0.716, p=0.809, respectively). The change in CRT in eyes with higher early fluorescence was significantly higher than eyes with lower fluorescence. Eyes with higher fluorescence had a wider foveal avascular zone. Conclusion: This study demonstrated that more vascular and cellular damage is related to higher hyperfluorescence level in the early period of FFA. The prognostic significance of this finding deserves to be evaluated with further studies.
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