Abstract

Background: Multiple myeloma is a multifocal hematological disorder, which shows a proliferation of malignant plasma cells in the bone marrow, it represents approximately 1% of all malignancy, causing about 20% of deaths from hematological malignancies. Cyclin D1 is considered an important factor in the cell cycle control; dysregulation of cyclin D1 has an oncogenic role in multiple myeloma patients and can affect their prognosis

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