Abstract
TRANSECTION of the hypophysial stalk in the rabbit prevents the occurrence of I mating induced ovulation and the associated corpus luteum formation (i). J L Failure of stalk-cut animals to ovulate is not due to an absence of ovulation producing material in the hypophysis. The glands of such animals contain normal concentrations of follicle stimulating and luteinizing substances (2). Additional evidence that the pars distalis retains some functional ability after transection of the hypophysial stalk is furnished by the fact that the ovaries do not become atrophic. Follicular development occurs to such a degree that ovulation can be produced readily by injections of pregnancy urine extracts (1). Ovarian reactivity to the ovulation producing material of pregnancy urine decreases rapidly following removal of the hypophysis (3). White and Leonard (4) found that in order to induce ovulation in rabbits injected 1 hour after hypohysectomy it was necessary to use 50% more pregnancy urine than the minimal dose for ...
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