Abstract
As was first pointed out by Heape (1) and verified by Hammond and Marshall (2) ovulation in the rabbit occurs normally ten to twelve hours following copulation. The work of Evans (3) on the luteinizing effect of anterior lobe extracts upon rat ovaries, and that of Smith and Engle (4) and Zondek and Aschheim (5) on the gonad-stimulating effects of the anterior lobe, as well as that of Smith (6) showing that hypophyseetomy caused cessation of the oestrus cycle in the rat all indicated a relationship existing between the anterior lobe and the ovary. Bellerby (7) working with hypophyseal extracts and Friedman (8) working with pregnancy urine were able to induce ovulation in the unbred rabbit and Fee and Parkes (9) have demonstrated that hypophyseetomy within one hour following copulation prevents ovulation. This, in broad outline, is the evidence for the belief now commonly held, that ovulation in the rabbit is the end product of two reactions: first, an activation of the anterior lobe probably by means of th...
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