The primary clinic application of laparoecopic-assisted continuous circulatary hyperthermic per fusion intraperitoneal chemotherapy in the treatment of malignant ascites

Abstract

Objective To investigate the measurement,feasibility and clinic effect of laparoscopic-assisted continuous circulatary hyperthermic perfusiou intraperitoneal chemotherapy (LAHPIC) in the treatment of malignant aseites from peritoneal carcinomatosis.Methods From March 2006 to March 2008 LAHPIC approach was performed on 21 patients affected by malignant ascites secondary to peritoneal carcinomatosis.Every patient was performed LAHPIC for three times,the first time were completed in operative room by general anesthesia,the second and third were performed in intensive care unit (ICU),solutiou was delivered continuous circulatary perfusion inflow peritoneal cavity by 450-600ml/min in every LAHPIC,and intraperitoneal perfusion of mitomycin-C and cisplatin was delivered for 90min with an inflow temperature of 43 degrees C.And these patients were performed long-term followed up LAHPIC later.Rasults LAHPIC course was uneventful in all cases,and mean operative time was 80min.Clinical complete regression of ascites was achieved in 19 patients treated,and partial remission achieved in 2 patients.No postoperative deaths and complication related to the procedure occurred in this study.The patients KPS grades rised (P＜0.01),the tumor marker decreased,and the patient general status improvement,satisfy clinic effectiveness had been acquired in these patients treated by laparoscopic LAHPIC.Conclusions LAHPIC appears to be a safe,feasibility and effective procedure to treat debilitating malignant ascites from unresectable peritoneal carcinomatosis,which has less trauma and pain in patients with quick postoperative recovery,would have a clinic good perspective in future. Key words: Laparoscopy; Intraperitoneal; Hyperthermic perfusion; Chemotherapy; Malignant tumor; Malignant aseites