Clinical efficacy of Nedaplatin and oxaliplatin in hyperthermic peritoneal perfusion treatment of patients with malignant ascites

Abstract

Objective To investigate the effect of Nedaplatin and oxaliplatin in hyperthermic peritoneal perfusion treatment of patients with malignant ascites as well as its adverse chemotherapy effect.Methods Fifty seven ovarian cancer patients of with ascites were randomly divided into the observation group(32 cases) and the control group (25 cases).Patients were respectively treated with nedaplatin or oxaliplatin for intraperitoneal hyperthermic perfusion.The nedaplatin plus saline 2 000 ml or oxaliplatin plus 5％ glucose 2 000 ml were heated with hyperthermic perfusion machine to 42-43℃,and then infusion into abdominal cavity of patients at certain speed.The efficiency and toxicity of the two groups after reperfusion were recorded.Results All patients were followed up for 6 months.The control rate of ascetic fluid in observation group was 90.6％,of which,CR was 34.4％ (11/32) and PR 56.2％ (18/32).The control rate of ascetic fluid in control group was 68.0％,of which,CR was16.0％ (4/25) and PR was 52.0％ (13/25).The difference between observation and control group was statistically significant in terms of therapy efficacy(x2 =39.36,P ＜0.05).The side effect in patients of observation group was slight than that in control group.Conclusion Nedaplatin for intraperitoneal hyperthermic perfusion with oxaliplatin has advantages with good curative effect,low toxicity,which can improve the compliance of chemotherapy in order to complete chemotherapy cycles. Key words: Ovarian cancer; Hyperthermic peritoneal perfusion; Nedaplatin; Oxaliplatin; Chemotherapy effect