Abstract
BackgroundHyperuricemia is a common and serious public health problem. There has been no broad epidemiological survey of hyperuricemia in China, especially in Tibetan area. This study was therefore investigated the prevalence of hyperuricemia and its correlated factors among people aged 18–85 years in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China.MethodsWe carried out a cross-sectional study among 3093 participants in Ganzi Tibetan Autonomous Prefecture using questionnaires in face-to-face interviews, anthropometric measurements and biochemical tests. We included 1416 subjects with complete data including serum uric acid and medical history to analyze the prevalence of hyperuricemia and correlated factors. Hyperuricemia was defined as a fasting serum uric acid level higher than 420 μmol/L in men and 360 μmol/L in women.ResultsThe overall crude prevalence of hyperuricemia was 37.2%, and was greater in men than women (41% vs 34.4%, P = 0.011). The age-adjusted prevalence was 33.0%. Characteristics linked to hyperuricemia were farmers-herdsmen (OR: 1.749, 95% CI: 1.022–2.992), low to moderate education level (low OR:1.57, 95% CI: 1.102–2.237; moderate OR: 1.86, 95% CI: 1.167–2.963), current drinking (OR: 1.795, 95% CI: 1.193–2.702), hypertension (OR: 1.48, 95% CI: 1.091–2.006), higher body mass index (1 unit increase) (OR: 1.116, 95% CI: 1.077–1.156) and higher serum creatinine (1 unit increase) (OR: 1.046, 95% CI: 1.034–1.059). Serum uric acid was positively related to triglycerides and total cholesterol and negatively related to high density lipoprotein cholesterol in all subjects. Hyperuricemia was a risk factor for high triglyceride ((OR: 2.13, 95% CI: 1.156–3.9266) and high total cholesterol (OR: 2.313, 95% CI: 1.364–3.923) in men and for high low-density lipoprotein cholesterol (OR: 2.696, 95% CI: 1.386–5.245) in women.ConclusionThere is a high prevalence of hyperuricemia in Ganzi Tibetan Autonomous Prefecture. The government needs to prevent and manage hyperuricemia in this area.
Highlights
Hyperuricemia is a common and serious public health problem
Weight, heart rate, serum uric acid, glucose and serum creatinine were significantly greater for men than women
Serum cholesterol, serum HDL cholesterol and glucose were significantly greater in women than men, with no difference in Body mass index (BMI), Waist circumference (WC), Hip circumference (HC), Waist-to-hip ratio (WHR), Systolic blood pressure (SBP), diastolic blood pressure (DBP), serum low-density lipoprotein cholesterol (LDL-C) and serum TG between the two genders
Summary
There has been no broad epidemiological survey of hyperuricemia in China, especially in Tibetan area. Hyperuricemia is defined as a fasting serum uric acid higher than 420 μmol/L in men and 360 μmol/L in women [1] It causes gout and urinary calculi and is related to a variety of comorbidities, including cardiovascular diseases, chronic kidney disease, metabolic syndrome, diabetes mellitus [2]. The United States National Health and Nutrition Examination Survey 2007–2008 study showed that the prevalence of Hyperuricemia was 21.2% among men and 21.6% among women in America [3]. The China National Survey of Chronic Kidney Disease showed that the age-adjusted prevalence of hyperuricemia among Chinese adults in 2009–2010 was 8.4% (9.9% in men and 7.0% in women) [4]. There have been few broad epidemiological surveys of hyperuricemia in China, especially in remote and underdeveloped areas
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