Abstract
Aim: Approximately 210 million peoples worldwide are estimated to be infected with chronic HCV. Nowadays, with the use of direct-acting antiviral agents, sustained viral response rates of more than 95% have been achieved in HCV. In our country, these drugs have been used for the last two years. The desired results could not be reached in the number of patients reaching treatment. In this study, we investigated the prevalence of HBsAg and HCV in Aksaray. In addition, we aimed to reveal the demographic characteristics of patients infected with HCV, their awareness about the disease and the rates of access to treatment. Material and methods: In this study, 11716 patients admitted to Aksaray Training and Research Hospital Gastroenterology, Infectious Diseases Outpatient Clinic and Endoscopy Unit between January 2016 and October 2018 were retrospectively screened. HCV positive patients were called from their contact numbers. Results: HBsAg was detected in 244 (2.08%) and anti-HCV positivity in 71 (0.6%) of 11716 patients. Fifty-three patients with HCV were included in the study. 16 patients could not be reached. Nine of these patients were treated with new treatment regimens at the external center. Nine patients were reached during this study and were provided access to treatment. All of these patients were able to tolerate treatment and a permanent viral response was found. Conclusion: Direct effective antiviral agents are effective and safe drugs in patients with HCV. Additional efforts and means of communication are needed to enable patients to access drugs.
Highlights
Aim: Approximately 210 million peoples worldwide are estimated to be infected with chronic hepatit C virüsü (HCV)
With the use of direct-acting antiviral agents, sustained viral response rates of more than 95% have been achieved in HCV
We investigated the prevalence of HBsAg and HCV in Aksaray
Summary
Aksaray ilindeki HBsAg/HCV prevalansı, HCV’li hastaların demografik verileri ve yeni tedavilere ulaşım oranları. Günümüzde doğrudan etkili antiviral ajanların kullanılmasıyla HCV’de tedavi başarısı %95’in üzerinde kalıcı viral yanıt oranlarına ulaşılmıştır. Bu çalışmada Aksaray İlindeki HBsAg ve HCV prevalansını araştırdık. Ayrıca HCV ile enfekte olan hastaların demografik özellikleri, hastalıkla ilgili farkındalıklarını ve tedaviye ulaşım oranlarını ortaya çıkarmayı amaçladık. Gereç ve Yöntem: Bu çalışmada Ocak 2016 ile Ekim 2018 tarihleri arasında Aksaray Eğitim ve Araştırma Hastanesi Gastroenteroloji, Enfeksiyon hastalıkları polikliniği ve endoskopi ünitesine başvuran 11716 hasta geriye doğru tarandı. Bulgular: 11716 hastanın 244’ünde (%2,08) HBsAg ve 71’inde (%0,6) anti-HCV pozitifliği saptandı. Dokuz hastaya bu çalışma sırasında ulaşılarak tedaviye ulaşmaları sağlandı. Bu hastaların tamamının tedaviyi tolere edebildiği ve kalıcı viral yanıt sağlandığı tespit edildi. Anahtar kelimeler: hepatit C virüsü, direk etkili antiviral ilaçlar, kalıcı viral yanıt
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