Abstract
Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (ORadditive = 1.58, 95% CI 1.23–2.03, p < 0.001, ORrecessive = 1.58, 95% CI 1.22–2.04, p = 0.001). Furthermore, the G allele of rs1799971 polymorphism (OPRM1 gene) increased the risk of familial aggregation (ORadditive = 1.99, 95% CI 1.36–2.91, p < 0.001 ORdominant = 2.01, 95% CI 1.35–3.01, p < 0.001). In subgroups of psoriatic patients with history of early onset and familial aggregation effect allele ‘C’ of rs1229984 showed association in the additive and recessive models (ORadditive = 2.41, 95% CI 1.26–4.61, p < 0.01, ORrecessive = 2.42, 95% CI 1.26–4.68, p < 0.01). While effect allele ‘G’ of rs1799971 (OPRM1) also associated with increased risk of early onset and familial aggregation of psoriasis in the additive and dominant models (ORadditive = 1.75, 95% CI 1.27–2.43, p = 0.001, ORdominant = 1.82, 95% CI 1.26–2.63, p = 0.001). Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population.
Highlights
Psoriasis is a common chronic inflammatory disease affecting 1–4% of the world population, with strong genetic as well as environmental factors in the background [32] affecting the onset, clinical manifestation and the course of the disease [6]
We aimed to address if genetic factors driving alcohol consumption could be linked to psoriasis, or whether primarily environmental factors contribute to the increased alcohol consumption of psoriatic patients [9]
Whether this association is driven by genetic factors has not been answered yet and in this study we evaluated the relationship between 23 SNPs related to increased alcohol intake and dependence in a Hungarian psoriasis group
Summary
Psoriasis is a common chronic inflammatory disease affecting 1–4% of the world population, with strong genetic as well as environmental factors in the background [32] affecting the onset, clinical manifestation and the course of the disease [6]. Alcohol consumption is one of the primary environmental factors, showing a direct link with psoriatic risk [3, 11, 20, 37, 49, 50], further studies are needed to confirm if excessive alcohol consumption correlates with disease. At least to our knowledge, no studies were carried out to investigate the possible genetic background for alcohol consumption in psoriasis populations, to explore whether psoriatic patients have a genetically increased risk for alcohol consumption
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