Abstract
Hemoglobinopathies, common genetic disorders of hemoglobin, can be prevented by population screening and genetic counseling. Identification of these disorders is immensely important epidemiologically and aid in prevention of more serious hemoglobin disorders. Thalassemia is the commonest monogenic disorder in India, which belongs to the thalassemia belt of the world. The present study was undertaken to find out the characteristics of β-thalassemia trait and spectrum of this disorder among the rural population, screened under the hospital-based screening program in West Bengal, a state in eastern part of India. This study was carried out in school and college students, newly married couples and pregnant women after proper counseling in the rural areas of five southern districts of this state. Blood samples were tested by high-performance liquid chromatography. Total 1429 β-thalassemia traits were detected by random screening from this population. The mean value of HbA2 of the study population, having β-thalassemia trait is 4.9%. The prevalence (10.5%) of β-thalassemia trait in West Bengal is higher than other parts of the country. These data are likely to help us in future planning for screening programmes in rural areas of West Bengal, India.
Highlights
Introduction of rural areas of WestBengal for screening of individuals for the thalassemia carrier state and for the propagation of awareness
Seminars on thalassemia are organized on a regular basis in rural areas with help from local administrative authorities, volunteers, institutional heads, representatives from clubs, village heads, religious leaders of all
Hemoglobinopathies are a group of genetic this study was to determine the prevalence of liquid chromatography (HPLC) machine.[10]
Summary
This study was part of a social service scheme conducted by the Thalassemia Society of Midnapore District, which is a nonprofit voluntary organization. The field survey was done under direct guidance of the authors. The Thalassemia Society of Midnapur District regularly arranges camps in different districts flict of interests. ©Copyright S.K. Maji et al, 2014 Licensee PAGEPress, Italy Thalassemia Reports 2014; 4:2188 doi:10.4081/thal.2014.2188 pregnant women to come forward for voluntary blood testing. This study was conducted in the villages of 5 (five) southern districts of Paschim Midnapur, Purba Midnapur, Purulia, Hooghly and Burdwan; within the state of West Bengal, India
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