Abstract
Background: To find out the prevalence of hemoglobinopathies by screening large population in West Bengal from Eastern India. Materials and Methods: A total of 50,487 subjects are screened for hemoglobinopathies from June 2010 to August 2013. A 2.5 ml of venous blood samples were collected in the tri-potassium EDTA vacuum container from each subject and tested with automated blood cell counter (Sysmex KX21) for red cell indices. Diagnosis of hemoglobinopathies was done by VARIANT TM (Bio-Rad Laboratories, Hercules, CA, USA) high performance liquid chromatography (HPLC). Results: Out of 50,487 cases, 44,620 (88.38%) had normal and 5,867(11.62%) showed abnormal hemoglobin fractions on HPLC. Of these, 5,180(10.26%) were heterozygotes (traits) and 687(1.36%) cases were either homozygotes or compound heterozygote for different types of hemoglobinopathies. The following hemoglobinopathies were present: β-thalassemia trait 6.61%, HbE trait 2.78%, sickle cell trait 0.56%, HbD-Punjab trait 0.21%, β-thalassemia major 0.73%, HbEE 0.05%, compound heterozygosity for HbE-β-thalassemia 0.42%, and HbS-β-thalassemia 0.15%. Conclusion: Among the hemoglobinopathies, β-thalassemia trait (6.61%) and HbE trait (2.78%) are prevalent in rural Bengal.
Highlights
To find out the prevalence of hemoglobinopathies by screening large population in West Bengal from Eastern India
A total of 50,487 cases were subjected to study from different districts of rural areas of West Bengal by arranging camps and awareness programmes in the villages
The society served their services in schools, colleges and university for screening of individuals for detection of different hemoglobinopathies
Summary
To find out the prevalence of hemoglobinopathies by screening large population in West Bengal from Eastern India. Materials and Methods: A total of 50,487 subjects are screened for hemoglobinopathies from June 2010 to August 2013. Diagnosis of hemoglobinopathies was done by VARIANTTM (Bio-Rad Laboratories, Hercules, CA, USA) high performance liquid chromatography (HPLC). Results: Out of 50,487 cases, 44,620 (88.38%) had normal and 5,867(11.62%) showed abnormal hemoglobin fractions on HPLC. 5,180(10.26%) were heterozygotes (traits) and 687(1.36%) cases were either homozygotes or compound heterozygote for different types of hemoglobinopathies. The following hemoglobinopathies were present: β-thalassemia trait 6.61%, HbE trait 2.78%, sickle cell trait 0.56%, HbD-Punjab trait 0.21%, β-thalassemia major 0.73%, HbEE 0.05%, compound heterozygosity for HbE-β-thalassemia 0.42%, and HbS-β-thalassemia 0.15%. Conclusion: Among the hemoglobinopathies, β-thalassemia trait (6.61%) and HbE trait (2.78%) are prevalent in rural Bengal
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medicine and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
