Abstract
Acute Myocardial Infarction (AMI) is a clinical manifestation of coronary atherothrombosis and is the important causes of death. Many factors play a role in AMI. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylethanolamine (aPEA) antibody has been detected in various autoimmune diseases and anti-phospholipid antibody syndrome. The study of aPEA antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of coronary atherothrombosis and AMI. This study was aimed to evaluate whether prevalence of aPEA antibodies, in patients with AMI and to analyze their relationship with traditional cardiovascular risk factors. The prevalence of aPEA IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as a control group. Sera from two groups were tested to evaluate the presence of aPEA IgG and IgM isotypes by ELISA method. The frequencies of positive test for aPEA IgG were 12.22 and 2.22% among patients and controls respectively with significant difference (p = 0.007). The aPEA IgM frequencies were 3.33 and 0.00% in patients and the controls, with significant difference (p = 0.005). According to the results of this study, aPEA antibodies have a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and coronary atherothrombosis. Further studies with larger sample size of patients and healthy people are needed to explore the role of aPEA antibodies in coronary atherothrombosis.
Highlights
Arterial thrombosis is the collective among Cardiovascular Diseases (CVD) is the result of environmental factors and personal
The association between positive aPEA IgG and IgM tests and selected cardiovascular risk factors were examined in this study
There was not found any significant association between positive aPEA IgG and IgM tests with Type-I Diabetes Mellitus (DM), TypeII DM, age, sex, LDL, HDL, TG, total cholesterol and adjusted smoking
Summary
Arterial thrombosis (myocardial infarction, manifestation of coronary atherothrombosis and cerobrovascular accident, angina) is the collective among Cardiovascular Diseases (CVD) is the result of environmental factors and personal. Abdolreza Sotoodeh Jahromi et al / OnLine Journal of Biological Sciences 13 (4): 126-130, 2013 predispositions Factors such as low serum adiponectin (Shojaie et al, 2009a) and low annexin V levels (Shojaie et al, 2009b) and infectious diseases such as Mycoplasma pneumonia (Pourahmad et al., 2009) are a part of involving factors in AMI. It has been demonstrated that the immunopathological such as anti-beta glycoprotein-I antibody (Shojaie et al., 2011), Anti-Phosphatidylserine antibodies (Jahromi et al, 2013) and Inflammatory processes (Jahromi et al, 2010a) have important roles in the initiation and development of AMI It seems that several subspecificities of antiphospholipid antibodies may occur in the patients with MI and some evidence suggest that these antibodies may contribute to the development of MI (Vaarala, 1998). Phospholipid Antibodies (aPL) were shown to target anionic phospholipids and other plasma proteins, including phosphatidylethanolamine (PEA), protein C, protein S, ß2-Glycoprotein I and annexin V (Tincani et al, 2010)
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