Abstract
Chitosan is a novel biocompatible, biodegradable polymer for potential use in tissue engineering. In this work, ZnO@chitosan (CS)@gelatin (GEL) composite scaffolds were prepared by combining coaxial electrospinning methods and RF magnetron sputtering. And polyethylene oxide (PEO) was added into CS solution to improve spinnability. The prepared CS-PEO@GEL nanofibers were characterized using SEM and TEM. The prepared ZnO@CS-PEO@GEL composite scaffolds were characterized using SEM, XRD and LSCM studies. The composite scaffolds were three-dimensional network structured. In addition, cytotoxicity of the composite scaffolds were studied by CCK-8 assay. The scaffolds showed good biocompatibility and cytocompatibility, according to this study.
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