The preoperative assessment and surgical approaches of epilepsy induced by tuberous sclerosis complex

Abstract

Objective To summary preoperative assessment and surgical approaches of tuberous sclerosis complex (TSC) patients.Methods We retrospectively analyzed the clinical data of 20 cases with epilepsy induced by TSC from June 2004 to June 2011 in Beijing Sanbo Brain Hospital.All the patients were fellowed up 1-5 years.Results Different surgical approaches had been made based on the pre-operative assessment.The pure nodules resection were made of 8 patients.The nodules resection were made after subdural electrodes implantation of 1 patient.The lobotomy was made of 4 patients.The nodule resection combined bipolar electro-coagulation on functional cortex (BCFC) were made of 2 patients.The lobotomy combined disarticulation was made of 1 patient.VNS was made of 2 patients.Corpus callosotomy was made of 2 patients.All the patients were fellowed up 1-5 years,averaged 2.9 years.Engel Ⅰ,in 11 patients ;Engel Ⅱ,in 2 patients; Engel Ⅲ,in 5 patients; Engel Ⅳ,in 2 patients.The effective rate was 90％(18/20).Conclusions By the accurate assessments,the epilepsy seizure which is induced by TSC can been controlled or reduced with different surgical approaches. Key words: Tuberous sclerosis complex(TSC) ; Epilepsy ; Epilepsy surgery