The preliminary research of contrast-enhanced ultrasound in differential diagnosis of different molecular subtypes of breast cancer

Abstract

Objective To explore the value of contrast-enhanced ultrasound (CEUS) in differential diagnosis of different molecular subtypes of breast cancer. Methods Sixty-two cases breast cancer patients with 62 breast lesions confirmed as breast cancer by postoperative pathology were selected. Referencing of St. Gallen standard and according to immunohistochemical markers of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2) expression, all the cases were divided into Luminal epithelium A or B (Luminal A/B)subtype(26 patients ), Her-2 over-expression subtype(16 patients) and triple negative (TN) subtype(20 patients). CEUS and routine ultrasonography were performed for all patients before surgery, and the contrast enhancement patterns and perfusion parameters were recorded. Whether there was a difference between the contrast enhancement patterns and perfusion parameters in different subtypes of breast cancer was analyzed. Results ①The contrast enhancement pattern showed more radioactive gathering(76.9%, P 0.05). Conclusions Different molecular subtypes of breast cancer have different contrast enhancement patterns and perfusion parameters, CEUS can provide valuable imaging information for the diagnosis of breast cancer molecular typing before surgery. Key words: Contrast-enhanced ultrasound; Breast cancer; Molecular subtype