Abstract
Objective To observe the expression of Cyclin D1 in different molecular subtypes of breast cancer and its relationship with estrogen receptor (ER),progesterone receptor (PR).Methods Typing molecular subtypes in 66 cases of breast cancer by immunohistochemical method to detect the expression of ER,PR,human epidermalgrowth factor receptor-2 (Her-2),creatine kinase 5/6 (CK5/6)and epidermal growth factor receptor(EGFR).And detect the expression of Cyclin D1 in different molecular subtypes in 66 cases with breast cancer to analysis the relationship between it and the molecular subtypes and ER,PR.Results (1) Cyclin D1 in the luminal A,luminal B,naked expression,over expression of Her-2 and basal like breast carcinoma positive expression rate decreased,respectively 85.71％,83.33 ％,75.00％,66.67％,44.44％,the difference was statistically significant (P ＜ 0.05).(2) The positive expression of ER was positively correlated with Cyclin D1 positive expression (r =0.436,P ＜0.05) ; and the positive expression of PR had no significant correlation with Cyclin D1 positive expression (r =0.048,P ＜ 0.05).Conclusion Cyclin D1 can be used as predictors of cancer prognosis and endocrine treatment in breast cancer. Key words: Breast cancer; Molecular subtype; Cyclin D1; Estrogen receptor; Progesterone receptor
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