The predictive value of liver tests for the presence of liver metastases.

Abstract

To analyze the predictive value of biochemical liver tests in patients with malignant melanoma, breast, colorectal or lung cancers at the time of diagnosis of liver metastases. A retrospective review of patients with the above-mentioned solid tumors at MedStar Georgetown University Hospital from 2016-2020. The highest optimal cutoff according to sensitivity and specificity for the presence of liver metastases was for AST ≥1.5×ULN for melanoma, lung, and breast cancers and ≥2×ULN for colorectal cancer, ALT ≥1.25×ULN for melanoma, breast and colorectal cancers and ≥1.5×ULN for lung cancer, and ALP ≥1.5×ULN for melanoma, breast and colorectal cancers. Using thresholds of liver enzymes above the ULN may improve the diagnostic accuracy for the presence of liver metastases.