Abstract
The vibration disease occupies one of leading places among occupational diseases. To decrease vibration pathology and to diminish number of cases of disability an early pre-clinical detection of harmful effect of vibration on organism of worker is needed. The purpose of study is to develop mode of diagnostic of early indications of health disorders of working individuals under local vibration impact. The immune enzyme technique was applied to immunologically examine 40 males workers in contact with local vibration. In workers with pre-clinical indications of health disorders due to effect of vibration alterations were established concerning content of immunoglobulins and cytokines characterized by lowering of concentrations of IgA, IgM, TNFα and also increasing of production of pro-inflammatory cytokine IL-1β and anti-inflammatory cytokine IL-4. The increasing of serum concentrations of neuro-specific protein S-100β is established. The proposed mode permits detecting early indications of health disorders in workers contacting with local vibration in condition of applying minimal number of the most informative diagnostic indices that promotes decreasing of volume of clinical analyses.
Published Version
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