Abstract
Data obtained from expression microarrays enables deeper understanding of the molecular signatures of infectious diseases. It provides rapid and accurate information on how infections affect the clustering of gene expression profiles, pathways and networks that are transcriptionally active during various infection states compared to conventional diagnostic methods, which primarily focus on single genes or proteins. Thus, microarray technologies offer advantages in understanding host-parasite interactions associated with filarial infections. More importantly, the use of these technologies can aid diagnostics and helps translate current genomic research into effective treatment and interventions for filarial infections. Studying immune responses via microarray following infection can yield insight into genetic pathways and networks that can have a profound influence on the development of anti-parasitic vaccines.
Highlights
Filarial infections caused by Wuchereria bancrofti and Brugia species (lymphatic filariasis (LF) and Onchocerca volvulus), affect almost 200 million individuals globally
Microarrays offer a comprehensive overview of gene expression, transcriptomics as well as insight into which signaling pathways and networks are affected during infections
Given that the host immune response is primarily dependent on the integration of several signals induced by the presence of the parasites, it is critical to study the specific signaling pathways that are significantly impacted during filarial infections
Summary
Filarial infections caused by Wuchereria bancrofti and Brugia species (lymphatic filariasis (LF) and Onchocerca volvulus (onchocerciasis)), affect almost 200 million individuals globally. The advent of microarray technology has revolutionized biomedical research [10] and has deepened researchers’ insight into. The advent of microarray technology has revolutionized biomedical research [10] and has deepened researchers’ insight into host immune responses to infections [11]. It has advanced understanding of complex and importantofbiological host immune responses to infections [11]. The early larval development of the filarial stages in both vector and mammalian hosts. In of individuals with LF, worms reside in the worms reside in the afferent lymphatic vessels, scrotal regions in males or breast areas of females.
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