Abstract
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis and treatment, including the occurrence, development, progression, metastasis, and treatment of oncologic disease. It covers basic, translational and clinical research related to cancer cell biology, genomics, precision medicine, oncology internal medicine, radiotherapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Highlights
Programmed cell death protein 1 (PD-1), a member of the CD28 receptor family, is expressed by activated lymphocytes and inhibits their proliferation functions after binding to PD-1 ligands such as PD-L1[1]
The patients were diagnosed with various solid cancers including: esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), hepatocellular carcinoma, pancreatic cancer, breast cancer and ovarian cancer
To detect the expression of PD-1 by tumor-infiltrating lymphocytes (TILs), all studies used immunohistochemistry, except for 2 studies[22,23], which used quantitative immunofluorescence, but the proportion of PD-1 expression was consistent with the others in that study
Summary
Programmed cell death protein 1 (PD-1), a member of the CD28 receptor family, is expressed by activated lymphocytes and inhibits their proliferation functions after binding to PD-1 ligands such as PD-L1[1]. Several previous studies have reported the PD-1 by TILs is more than a predictive biomarker but as a worse prognosis marker in multiple solid tumors such as gastric cancer[4], non-small cell lung cancer (NSCLC)[5], renal cell cancer[6] and nasopharyngeal cancer[7]. Another studies showed that PD-1 expression is associated with favorable survival in breast cancer[8], glioblastoma[9], metastatic melanoma[10], ovarian cancer[11] and primary human papillomavirus-positive head and neck cancers[12]. The different of tissue samples, detection methods and evaluation criterions might be partly responsible for the inconsistent results
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