Abstract
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis and treatment, including the occurrence, development, progression, metastasis, and treatment of oncologic disease. It covers basic, translational and clinical research related to cancer cell biology, genomics, precision medicine, oncology internal medicine, radiotherapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Highlights
Since identifying cellular resistance mechanisms by understanding the differences in cell response at the molecular level is of fundamental importance to improving the protocol and to increase the success of the therapy[135], we have recently shown that breast cancer cells are differently affected by methylene blue (MB) concentrations at the same light dose in MB-photodynamic therapy (PDT) and that non-malignant human breast cells are significantly more resistant to the therapy compared to the malignant ones[26]
The challenges in fighting the disease rely on intrinsic tumor resistance properties, molecular heterogeneity, and metastasis
Considering all the information provided one can conclude that there are almost no doubts that one relevant advantage of PDT over other cancer treatments is the possibility of generating less side effects to the patients
Summary
Overall, accumulating evidence indicates that the therapeutic efficacy of several antineoplastic agents, including PDT, relies on their capacity to influence the tumor-host interaction, tipping the balance toward the activation of an immune response specific for malignant cells, especially for metastasize cancer. Regarding the metastatic problem in breast cancer, this systemic complication represents the most complex challenge in PDT-treatment for this type of tumor, a study conducted with fourteen patients with more than 500 truncal metastases showed that all patients presented tumor necrosis and nine of them demonstrated complete responses[123].
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