Abstract
A study was made to determine the effect of galactosyl derivatives of hydroxy acids on selected microorganisms with probiotic features and on pathogenic bacteria associated with food, the digestive system and human skin. It was shown that the highest tested concentration (0.05 M) of the gluconic acid and glucoheptonic acid derivatives had a more favorable effect on the development of Lactobacillus bacteria than the corresponding concentration of lactobionic acid. The new bionic acids added to the culture medium at appropriate concentrations (0.05 M or 0.025 M gluconic acid derivative, 0.025 M or 0.0125 M glucoheptonic acid derivative) clearly stimulated the growth of L. brevis strain MG451814.1. The derivatives also supported the formation of biofilm by selected strains of L. acidophilus, L. brevis and L. casei. Antibacterial activity of gluconic and glucoheptonic acid derivatives was observed against selected strains: S. Choleraesuis, S. epidermidis and Staphylococcus aureus. This provides a prospect of limiting the development of antibiotic-resistant strains. It is anticipated that the newly acquired compounds have potential use as ingredients of dietary supplements, pharmaceutical preparations or cosmetics, because of the properties demonstrated as well as their similarity to currently known bionic acids.
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