The potential of Kebar grass extract on histopathological changes in kidneys of mice offspring from the parent exposed to carbofuran during the lactation period

Abstract

This research aims to know the potential of kebar grass extract (Biophytum petersianum) in reducing the impact of kidney damage in mice offspring during the lactation period from parents exposed to carbofuran. Carbofuran, kebar grass extract, and vitamin C are exposed orally postnatal day 1st until the 14th postnatal day after delivery. Forty-two mice adults in the lactation period were randomly into seven groups. This group consisted of K (aquadest control), P1 (carbofuran ¼ LD50 0.0125 mg/day), P2 (carbofuran 1/8 LD50 0.00625 mg/day), P3 (kebar grass extract 3.375 mg + carbofuran ¼ LD50), P4 (kebar grass extract 3.375 mg + carbofuran 1/8LD50), P5 (vitamin C 0.2 cc + carbofuran ¼ LD50), and P6 (vitamin C 0.2 cc + carbofuran 1/8 LD50). On the 15th day of experimental, offspring were randomly selected and dissected, and the kidney was taken to make a histopathology sample. This study shows that carbofuran caused increased tubular degeneration, necrosis, and inflammation (p<0.05). Kebar grass extract could decrease tubular degeneration, necrosis, and inflammation (p<0.05). Kebar grass extract was more effective than vitamin C in reducing kidney damage in mice offspring during the lactation period from parents exposed to carbofuran(p<0.05).