The potential effect of Alpha-linolenic acid against oxidative stress in non-alcoholic fatty liver disease

Abstract

Non-alcoholic Fatty Liver Disease (NAFLD) is characterized by fat accumulation in hepatocytes without secondary causes. Oxidative stress plays an important role in forming and progressing from NAFLD to non-alcoholic steatohepatitis (NASH). Alpha-linolenic acid (ALA) is an essential omega-3 (n-3) polyunsaturated fatty acid (PUFA) that has a high antioxidant effect. The purpose of writing this article is to determine the potential of ALA on oxidative stress in NAFLD. This article was made using an online search from 2013 to 2023, and six articles were obtained. From this review, we concluded that ALA has an antioxidant effect that can reduce the impact of oxidative stress in NAFLD, especially in liver tissue, which provides a hepatoprotective effect and regulates gene expression that can reduce oxidative stress in NAFLD.