Abstract
The authors gratefully acknowledge the support of the UK Biotechnology and Biological Sciences Research Council (BBSRC) for the work on cellular 2A-like sequences.
Highlights
The Potential Consequences for Cell Signaling by a Class of NOD-Like Receptor Proteins (NLRs) Bearing an N-terminal Signal Sequence
The open reading frame (ORF) of a number of NLR genes in S. purpuratus commence with a leader sequence with sequence similarity to ‘2A/2A-like’ oligopeptide sequences found in many virus genomes, which mediate an unusual translational ‘recoding’ event in which translation arrests at the C-terminus of 2A, but may recommence the synthesis of the downstream protein as a separate, entirely discrete, translation product [2,3,4,5]
Bioinformatic analyses suggested, that these S. purpuratus NLR 2A-like sequences might function as cotranslational signal sequences
Summary
The Potential Consequences for Cell Signaling by a Class of NOD-Like Receptor Proteins (NLRs) Bearing an N-terminal Signal Sequence. We showed this type of 2A-like leader sequence possessed both activities [6], and in this commentary we speculate upon the possibility that such a single gene could produce both cytoplasmic and membrane-bound/secreted forms of such NLRs.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
