Abstract
Editorial: NLR-Protein Functions in Immunity.
Highlights
Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
Since Janeway [1] and Matzinger [2] put forward two distinct concepts of innate immune recognition, arguing that the driving force that initiates immune reponses is the recognition of microbial patterns or endogenous danger signals, respectively, we have acquired a tremendous wealth of knowledge of the protein families involved
One important class of such intracellular pattern-recognition molecules (PRM) is the family of NOD-like receptor (NLR) proteins [9]
Summary
Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology. One important class of such intracellular PRM is the family of NOD-like receptor (NLR) proteins [9]. The proteins of the NLR family are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial defense, and adaptive immunity.
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