Abstract
The effects of acetazolamide on blood acid/base balance and the relationship of the latter to gastric lesion formation were studied in rats. Acetazolamide (200 mg/kg, s.c.) produced haemorrhagic gastric lesions which were accompanied by lowered arterial blood pH and HCO3- levels. High dose (6.2%) of NaHCO3 infusion normalised the arterial blood pH and decreased lesion formation. It also markedly raised the blood HCO3- level. However, a lower dose (3.1%) of the drug only raised the HCO3- to a normal level and slightly reduced the severity of ulceration. These results suggest that metabolic acidosis is the main causative factor while depletion of blood HCO3- may play a minor role in acetazolamide-evoked lesion formation in rat stomachs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
