Abstract
The effects of acetazolamide on blood acid/base balance and the relationship of the latter to gastric lesion formation were studied in rats. Acetazolamide (200 mg/kg, s.c.) produced haemorrhagic gastric lesions which were accompanied by lowered arterial blood pH and HCO3- levels. High dose (6.2%) of NaHCO3 infusion normalised the arterial blood pH and decreased lesion formation. It also markedly raised the blood HCO3- level. However, a lower dose (3.1%) of the drug only raised the HCO3- to a normal level and slightly reduced the severity of ulceration. These results suggest that metabolic acidosis is the main causative factor while depletion of blood HCO3- may play a minor role in acetazolamide-evoked lesion formation in rat stomachs.
Published Version
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