The possible relationship between thioredoxin-interacting protein and the pathogenesis of type 2 diabetes mellitus

Abstract

To investigate the plasma thioredoxin-interacting protein （TXNIP） levels in different glucose tolerance groups and discuss the relationship between TXNIP and insulin resistance/β-cell dysfunction in diabetes and prediabetes, and to investigate the potential relationship between TXNIP and interleukin-1β （ IL-1 β ）. According to oral glucose tolerance test, 93 participants were divided into 3 groups： diabetes mellitus group, prediabetes group, and normal glucose tolerance group. Plasma TXNIP, IL-1β, and other biochemical indices were measured. The relationship between TXNIP and glucose, IL-1 β, homeostasis model assessment for insulin resistance （HOMA-IR） , and homeostasis model assessment for β cell function （ HOMA-β ） were analyzed by using multiple linear regression techniques and Pearson＇s linear correlation analysis. Plasma TXNIP level was higher in prediabetes group compared with normal glucose tolerance group, but lower in prediabetes group compared with diabetes mellitus group [ （355.35 ±31.88 vs 274.36± 33.86,426.16 ± 63.15 ） pg/ml, P〈0.01 or P〈0.05 ]. TXNIP was positively correlated with IL-lβ and HOMA-IR, but negatively correlated with HOMA-β. Multiple linear regression analysis indicated that IL-1β exerted significant influence on TXNIP （P 〈 0. 05 ）. Plasma TXNIP level is affected by blood glucose concentration. There is a close relationship between TXNIP and IL-1 β In prediabetes patient, the TXNIP levels have already been raised. Key words: Thioredoxin-interacting protein ; Interleukin-1 β ; Diabetes mellitus, type 2 ; Insulin resistance