The plerotic effect of Yunnan Baiyao on renal injury after extracorporeal shock wave lithotripsy

Abstract

The objective of this study was to explore the protective effect of Yunnan Baiyao, a traditional Chinese herbal remedy, on renal function after extracorporeal shock wave lithotripsy (ESWL). 55 patients with renal pelvic stones were randomized to two groups: The control group (n = 25), where the patients were administered with Paishi Chongji (a traditional Chinese herbal granule for removing stones) after ESWL; and the study group (n = 30), where the patients were administered with Paishi Chongji and Yunnan Baiyao after ESWL. Urine microproteins and peripheral venous malondialdehyde (MDA), superoxide dismutase (SOD), endothelin-1 (ET-1) and nitric oxide (NO) were determined before ESWL, and at 24, 72 h and one week after ESWL. Urine, albumin (ALB), immunoglobulin (IgG) and beta-2microglobulin ( β2-MG) levels increased significantly, and urine THP decreased significantly after ESWL. Peripheral ET-1 and MDA at 24 and 72 h after ESWL were significantly lower, while peripheral SOD and NO were significantly higher in the study group than those in the control group (both P < 0.05). In conclusion, Yunnan Baiyao has a definite plerotic effect on renal injury after ESWL and could be spread widely for clinical use.