Effect of Huayu-Niaoshi decoction on renal injury in the patients with kidney stones after extra corporeal lithotripsy

Abstract

Objective To investigate the effect of Huayu-Niaoshi decoction on renal injury in the patients with kidney stones after extra corporeal lithotripsy(ESWL). Methods According to the inclusion criteria, 120 patients diagnosed with kidney stones were randomly divided into 2 groups with the random number table method, 60 patients in each group. Both groups were treated with double pulse extracorporeal shock wave lithotripsy(ESWL). Based on the ESWL, the control group was added with levofloxacin mesylate tablets for 3 days with the start of the day of the gravel; and the treatment group was treated with Huayu-Niaoshi decoction for 14 days based on the treatment of control group. The levels of serum endothelial endothelin 1(ET-1), malondialdehyde(MDA), urinary N-acetyl-β-Dglucosaminidase(NAG)N-acetyl-beta-d Glucosaminidase and urine beta 2 microspheres protein(beta eukaryotic 2-mg)were detected at time of gravel, 2 hours after gravel and 2 weeks after gravel. Results After 2 weeks treatment, the levels of urinary NAG(7.33 ± 4.39 U/L vs. 9.93 ± 5.10 U/L; Z=2.587, P=0.002), serum MDA(4.63 ± 0.90 nmol/ml vs. 7.29 ± 2.16 nmol/ml; Z=5.520, P=0.001), serum ET-1(35.06 ± 10.51 pg/ml vs. 46.90 ± 18.74 pg/ml; Z=3.315, P=0.001)and urine β2-MG(0.14 ± 0.19)mg/L vs. 0.19 ± 0.19 mg/L; Z=1.759, P=0.079)in the treatment group were significantly lower than those in the control group. Conclusions The Huayu-Niaoshi decoction can improve renal injury in the patients with kidney stones after extra corporeal lithotripsy. Key words: Kidney calculi; Lithotripsy; Kidney injury; Huayu-Niaoshi decoction; Endothelin; Malondialdehyde; N-acetyl-β-D glucosaminidase; β2-microglobulin